• Windows Vista, Linux and Mac OS X compatibility
• Improved Modeling Management
• Enhanced Data Management and Exploration
• Real time plotting of objective function value to monitor progress graphically.
• Efficient Post-Processing
• Enhanced Report-Friendly Outputs
• Automated Model Evaluation Methods
• Tracking and Audit Trail
• Detailed Help System
• Automated plots for individual parameter estimates (QQ-plots, QQ-log plots, and histograms of parameters)
• Automated plots for individual eta estimates (pairs plots, QQ-Plots and histograms of etas)

Use of PDx-Pop 4 requires a licensed copy of NONMEM 7
Ability to use multiple CPUs on multi-processor systems for batched runs.

• Real-time graphical monitoring of the objective function for all of the new estimation methods (including the Bayesian chain "caterpillar" plot and composite method runs)
• Button-operated interaction with the NONMEM run:
  • toggle on-off printing of numerical iteration (Iterations)
  • gracefully end a problem (Next)
  • end NONMEM run gracefully (Stop)
• Extended Summary Output (added features):
  • list of all estimation methods used in the run
  • statistical summary from final method
• Multi-CPU capability to run NONMEM batchs simultaneously (on multi-CPU systems)
• Graphical display of parameter sampling histories from Bayesian method
• Automated setup and run of multiple MCMC chains (with randomized initial parameter estimates) simultaneously
• Graphical display of multiple chains output (overlay plots of parameter histories and statistical summary from multiple MCMC chains)
• Automated initial parameter variation test (simultaneous runs with randomized initial parameters)
• New control file wizard to automate creation of control files including:
  • new estimation methods coding and options
  • composite methods (runs with multiple estimation methods)
  • automatic mu parameterization for library methods (ADVANS 1-4,10-12)
    • optional inclusion of error code for IPRE, IRES, IWRE
• PDx-Pop can now run user-written S-Plus and R scripts that can be linked to a specified run to create automated custom output.
• Free 30-day trial versions (with all features enabled) are available from our FTP site:  ftp://ftp.globomaxnm.com/Public/pdxpop/PDX-Pop4.0/

PDx-Pop 4.10 bug fixes:

• Fixed bug in summary.exe program where %RSE and confidence intervals were not calculated for unsuccessfully terminated runs with $COV UNCONDITIONAL.  
• Fixed bug in the PDx-Pop control files wizards that gave a switched variance identifier ([p]/[a]) for the additive and proportional components of the additive plus proportional error model that could have resulted in calculation errors for the residual variance related to standard errors.
• Fixed bug in PDx-Pop that failed to check and correct the run names for files with the .par, .eta, and .ext extensions with runs with Check Run Numbers checked
• Fixed bug in the param.exe program that limited the number of etas extracted from the .res file to 15 or less

• Recommended system requirements to run PDx-POP with other required software:
  • Intel or AMD pentium processor with 1 GB of memory (2 GB for Windows Vista)
  • Windows 2000, XP, or Vista, Linux (Ubuntu, Redhat tested), or Mac OS X (Tiger tested)
  • Graphics card and monitor capable of minimum resolution of 1280x800
  • SuperVGA or other Windows-compatible graphics card and monitor
  • CD-ROM disk drive
  • Microsoft mouse or other compatible pointing device
  • Supports all compatible printers
  • 100 MB free disk space for all required software (Interface space = 25 MB)
  • 100 MB of swap space/virtual memory
     

NONMEM V Level 1.1 or higher:
Compaq/Digital Visual Fortran (Versions 5.0 through 6.6), Intel Fortran 7.x - 10.x for Windows, or GNU g95, gfortran
MS Excel 97 or higher and Word 97or higher
Internet Explorer 6.0 or higher or other browser

NONMEM 7 or higher:
Intel Fortran compiler 8.0 or higher, or GNU g95, gfortran
MS Excel 97 or higher and Word 97or higher
Internet Explorer 6.0 or higher or other browser

R version 2.5.0 (or higher) or S-PLUS for Windows 6.1 (or higher)
(required for model evaluation features).
Xpose 4.0 for R or 3.104 for S-Plus (available at http://xpose.sourceforge.net/).

*Intel Visual Fortran requires Microsoft Visual Studio.

PDx-POP seat licenses are purchased on an annual basis. The base unit of purchase is a 3-seat annual license, with the ability to purchase individual annual seat licenses after base purchase for that year. PDx-Pop licensees are entitled to the following benefits:

• Full customer support
• Automatic updates and upgrades, exclusive of new functionality
• Advanced notice and priority shipment of new products and version releases